An introduction to Laxogenin
In your quest to take your muscle gains to the next level, the chances are that your research has introduced you to numerous substances, with each claiming that it is exactly what you need. If you are wondering whether laxogenin is a legit product, then you have come to the right place.
In recent years, more and more athletes and bodybuilders are turning to laxogenin as a safer alternative to steroids when looking to enhance their athletic performance as well as physiques.
Is laxogenin safe and effective? This review aims to find out.
What is Laxogenin?
Going by the chemical name 3beta-hydroxy-25D, 5alpha-spirostan-6-one, laxogenin is marketed as a muscle-building supplement. However, this compound belongs to a category of plant hormones known as brassinosteroids. Brassinosteroids work to boost growth in plants. They have a structure that is very similar to animal steroid hormones.
The main source of laxogenin is the Asian plant Smilax sieboldii, whose underground stems contain about 0.06 percent of the compound. Chinese onion bulbs also contain traces of the compound and, thus, are also routinely harvested to extracted laxogenin.
Nonetheless, most of the laxogenin that is sold in muscle-building supplements are derived from diosgenin, which is a common plant steroid.
However, as opposed to most muscle-building steroids, laxogenin is neither a steroid nor is it a prohormone. The implication, therefore, is that it is not converted into hormones such as dihydrotestosterone or testosterone. Also, it does not raise the user’s estrogen levels. Consequently, the user does not experience the common side effects that come from using steroids, such as:
- Kidney and liver damage
- Natural testosterone suppression and other types of hormonal imbalances
- Testing positive during anti-doping examinations.
Laxogenin is a legal supplement and is classified under the dietary supplements category.
How Does Laxogenin Work?
As mentioned earlier, laxogenin is not a prohormone, even though most vendors label it as such. This point is especially important to consider because prohormones work differently from how laxogenin works. A prohormone is one of the building blocks of a hormone. As such, if a product is labeled a prohormone, the body should be able to convert it to testosterone.
However, laxogenin affects entirely different pathways in the body since it is derived from plants.
Animal-derived compounds such as testosterone help you build muscle by stimulating your nuclear receptors. Laxogenin, however, attaches to surfaces of your cells, and this signals the cell to increase the rate of muscle building.
Laxogenin can achieve that feat by activating a protein known as protein kinase B or AKT1. The work of this protein is to enhance the rate of muscle building as well as preventing muscle protein breakdown.
Moreover, laxogenin also blocks the enzyme, which breaks down phosphodiesterase (cAMP). This results in increased levels of cAMP in the body. Higher cAMP levels result in a boost in the rate of fat breakdown.
The Anabolic Effects of Laxogenin
Laxogenin is believed to enhance the rate of muscle protein production by up to 200 percent. In an animal study featuring rats, the rats were given brassinosteroid derivatives whose structures mirror that of laxogenin. The researchers observed not only an overall increase in body weight, but also a significant increase in the amount of muscle protein in the kidneys, liver, heart, and legs.
Another key observation was that the rats upped their food intake. Consequently, they gained weight, but interestingly, it was lean body weight. The rats also displayed dramatic increases in their physical fitness levels. The study used both natural and synthetic versions of laxogenin. Both yielded similar results.
Studies done on phytoecdysteroids, which are a category of plant chemicals with a similar structure to brassinosteroids, revealed that they also increased the rate of muscle protein production and overall muscle growth in animals.
Benefits of Laxogenin
In addition to helping you make quick muscle gains, laxogenin also has the following potential benefits:
- Treating Cancer
In studies done on mice, laxogenin was found to help reduce lung tumor formation. Also, both natural and synthetic derivatives of the compound killed colon cancer and leukemia cells.
In other cell studies, both synthetic and natural brassinosteroid derivatives killed cancer cells as well as being effective at blocking tumor growth.
- Reducing Tissue Damage
In one cell study, a laxogenin derivative was found to prevent tissue damage resulting from oxygen deficiency and free radicals. These findings suggest that laxogenin might be able to neutralize oxidative stress. This might explain why the compound is so effective at enhancing muscle recovery.
What are the Side Effects of Laxogenin?
Laxogenin is among the rare types of compounds that have little to no side effects. The only reported side effect of using this substance is a headache. However, those who claim to have experienced a headache after using laxogenin said that it occurred after taking a high dose of the product.
As such, the worst-case scenario after using laxogenin is that you might experience a slight headache. And this is usually at doses of more than 150 mg, which is exceptionally high.
The primary reason behind laxogenin’s spike in popularity is that it allows users to experience monumental gains in muscle mass without any side effects. The gains it gives you are comparable to those one gets when they use steroids or prohormones. However, the latter products are known for side effects such as hair loss, roid rage, and other side effects that come with hormonal imbalances.
With laxogenin, however, you will not experience side effects that are typically associated with using steroids or prohormones. This is because laxogenin is a plant-based derivative and, as such, has no effect on your natural hormone levels. Therefore, it can also be used by females.
This means that you will not have to go through Post Cycle Therapy (PCT), which is a requirement after using any performance enhancer. Again, this is because laxogenin does not affect your endocrine system. Studies show that laxogenin and other brassinosteroids do not bind to your androgen receptors directly.
Simply put, using this compound allows you to speed up the muscle-building process, but without any side effects.
What is the Appropriate Dosage for Laxogenin?
Due to the vast differences in physical compositions among individuals, there currently isn’t one standard dosage that will work for everybody. As such, there are a lot of opinions about the optimal amount that one should take to achieve the desired effects.
Nonetheless, one clinical study recommended 100 mg per day as the optimal dosage for all users.
Our research, however, revealed that anywhere between 75 and 150 mg is what you need to get the results you want. This accounts for the differences in body compositions among different individuals.
To know what works best for you, consider starting with a dose of 75mg per day and observe the effects that you experience. You can then gradually work your way up towards 150mg as your body gets used to the compound. However, 150mg should be the threshold.
Even though there is no specific time that you are supposed to take laxogenin, it is recommended that you take it during breakfast. This gives it time to be absorbed throughout the day.
After discovering what your optimal dosage is, maintain it for about 8 weeks. After this period, consider taking a break from the compound for about 4 weeks. This is to ensure that your body doesn’t get used to it, and thus, stop responding to its effects.
For best results, consider stacking laxogenin with either of these products:
- Arachidonic acid
- Bodybuilding vitamins
- Phosphatidic acid
Why Would You Want to Use Laxogenin?
- It is a safer alternative to prohormones and steroids
Unfortunately, for a long time, steroids and prohormones were the only substances that could allow you substantial muscle mass gains within a short period. However, they also came with severe side effects. Laxogenin allows you to enhance your muscle mass growth safely.
- It acts fast
The effects of laxogenin kick in the moment you start using the compound, as such being ideal for anyone looking to enhance their performance quickly.
- Can be used for PCT
People withdrawing from steroids can use laxogenin to help maintain their gains.
- Complements protein supplements
Laxogenin works by signaling cells to increase the rate of muscle building. Cells, on the other hand, need protein to achieve that feat. By stacking laxogenin with protein supplements, therefore, you will be enhancing the rate of muscle building.
Before you use any product, you must first ensure that it is both safe and effective. In our research, we did not find any user complaining of any adverse side effects after using the compound. This means that it is safe.
In terms of effectiveness, most of its users claim to have experienced substantial increases in their strength levels, lean muscle growth, and enhanced muscle recovery.
If you are thinking about boosting your performance, you should give the compound a try. Be sure to share your experience with the product with us as well as other consumers.